ClinGen - Clinical Genome Resource

ClinGen is a National Institutes of Health (NIH)-funded resource dedicated to building an authoritative central resource that defines the clinical relevance of genes and variants for use in precision medicine and research.

Key Goals

Several key goals support our overall mission of building a genomic knowledge base to improve patient care:

  • Share genomic and phenotypic data between clinicians, researchers, and patients through centralized and federated databases for clinical and research use.

  • Develop and implement standards to support clinical annotation and interpretation of genes and variants.

  • Develop data standards, software infrastructure and computational approaches to enable curation at scale and facilitate integration into healthcare delivery.

  • Enhance and accelerate expert review of the clinical relevance of genes and variants.

  • Disseminate and integrate ClinGen knowledge and resources to the broader community.

Primary Funding Sources

ClinGen is primarily funded by the National Human Genome Research Institute (NHGRI), through the following three grants:

  • U41HG006834
  • U41HG009649
  • U41HG009650

ClinGen also receives support for content curation from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), through the following three grants:

  • U24HD093483
  • U24HD093486
  • U24HD093487

ClinVar is supported by the Intramural Research Program of the NIH, National Library of Medicine.