Clinical Domain Working Groups
TP53 Variant Curation Expert PanelMembership Documents
The TP53 gene provides instructions for tumor protein p53 (or p53). This protein acts as a tumor suppressor, regulating cell division by preventing cells from proliferating in an uncontrolled way.
The TP53 Variant Expert Panel will curate clinically relevant variants using the specified classification rules developed by the group. After interpreting variants using these specified guidelines, the group will make their final interpretations publicly available through ClinVar.
Expert Panel Status
ClinGen TP53 Variant Curation Expert Panel ApplicationExpert Panel Applications - August 7, 2019
ClinGen TP53 Expert Panel Specifications to the ACMG/AMP Variant Interpretation Guidelines Version 1Curation Activity Procedures - August 6, 2019
Expert Panel Membership
Membership spans many fields, including genetics, medical, academia, and industry.