Clinical Domain Working Groups

TP53 Variant Curation Expert Panel

Membership Documents

The TP53 gene provides instructions for tumor protein p53 (or p53). This protein acts as a tumor suppressor, regulating cell division by preventing cells from proliferating in an uncontrolled way.

The TP53 Variant Expert Panel will curate clinically relevant variants using the specified classification rules developed by the group. After interpreting variants using these specified guidelines, the group will make their final interpretations publicly available through ClinVar.

Expert Panel Status

Step 1
Step 2
Step 3
Step 4
Define Group
Completed
Develop Classification Rules
Completed Aug. 2017
Pilot Rules
Completed
Expert Panel Approval
Completed Aug. 2019

Documents

Expert Panel Membership

Membership spans many fields, including genetics, medical, academia, and industry.


Chairs

Coordinators
Please contact a coordinator if you have questions.