Variant Pathogenicity Curation

ClinGen variant curation utilizes the 2015 American College of Medical Genetics and Genomics (ACMG) guideline for sequence variant interpretation, which provides an evidence-based framework to classify variants.The results of these analyses will be deposited in ClinVar for community access.

Training Materials

Variant curation training aims to familiarize variant biocurators with general variant assessment information and ClinGen variant curation procedures and resources.

Learn More
Variant Pathogenicity Curation Interface

The ClinGen Variant Curation Interface is available for public use.

Learn More
Documents & Announcements

Documents and announcements related to Variant Pathogenicity Curation.

Learn More