Interested in Variant Curation? The following documents and presentations are available to help people learn and understand the variant curation process, as well as ClinGen's efforts to modify ACMG variant assessment criteria. In order to get involved with our Variant Curation activities, please fill out our volunteer survey: For questions about existing materials or requests for new materials, contact us at


Variant Curation Standard Operating Procedure, Version 1

Detailed documentation outlining the variant curation process.


SVI General Recommendations for Using ACMG/AMP Criteria

SVI provides general recommendations for using the ACMG/AMP criteria to improve consistency in usage and transparency in classification rationale.


Video Tutorials

Videos describing how to use the ClinGen Allele Registry, as well as an overview of searching the literature for sequence variant evidence, including tips and tricks on effective use of variant nomenclature in your search, where to look and common literature search speed bumps, and how to overcome them.


Live VCI Training

Attend a live Variant Curation Interface (VCI) training to learn more about how to enter information for variant curations. The ClinGen Community Curation Group will contact you regarding this training, once you have filled out the volunteer survey:


Attestation & Group Assignment

Once you have read through all of the information and attended a live VCI training session, you will be sent an attestation form to fill out. Once your attestation form is complete, the ClinGen Community Curation Group will contact you with your group assignment.



These OPTIONAL items include a video tutorial by Dr. Steven Harrison on "Variant Interpretation and the ClinGen Curation Interface Tool" and the Variant Curation Interface Help Document.

ViewBA1 Exception List

Supporting Documents - July 30, 2018

ViewStandards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

Supporting Documents - May 17, 2017 - The American College of Medical Genetics and Genomics (ACMG) previously developed guidance for the interpretation of sequence variants.