Expert Panels

Guidelines for Applying for Variant or Gene Curation Expert Panel Status

Download application for Gene Curation Expert Panel Status

Download application for Variant Curation Expert Panel Status

For submitted variants to be assigned Expert Panel status, applications for Expert Panel status must be reviewed and approved by the Clinical Genome Resource (ClinGen) program.

  1. Panel Membership - A membership list must be provided for review when requesting Expert Panel status for submissions. It is recommended that the expert panel include medical professionals caring for patients relevant to the disease gene in question, medical geneticists, clinical laboratory diagnosticians and/or molecular pathologists who report such findings and appropriate researchers relevant to the disease, gene, functional assays and statistical analyses. It is expected that the individuals comprising the expert panel process represent multiple institutions. It is expected that the individuals comprising the expert panel should be international in scope, and are considered by the community to be experts in the field based on publications and long-standing scope of work. ClinGen hopes that there is only one expert panel per gene and that the panel is inclusive of known experts in the field. Therefore, if you have expertise in a gene that is already evaluated by an expert panel, please consider joining efforts with the existing panel or provide justification for the necessity of an additional panel. We encourage newly forming expert panels to contact ClinGen (clingen@clinicalgenome.org) early in the process to discuss the formation of the panel.
     
  2. Conflict of Interest - Information should be provided with regard to any potential financial conflicts of interest of the panel members and how conflicts are managed.

Variant Curation Expert Panel (VCEP) Protocol

Download Variant Curation Expert Panel (VCEP) Protocol

This document is intended to provide guidance for existing groups or groups who are planning to assemble as Expert Panels for the curation of variants in clinically relevant genes, and describes the review and application process for obtaining Expert Panel status. Please note that this document applies to groups forming within the Clinical Genome Resource (ClinGen) only, but that groups forming outside of ClinGen are encouraged to follow this process as well. The VCEP Protocol is available for download at the bottom of this page.

Last updated November 2018