ClinGen considers the sharing of variant interpretations essential for supporting genomic medicine and a critical part of quality assurance for accurate genetic and genomic testing. Open and transparent sharing allows peer-review and knowledge dissemination to ensure the highest quality care of patients.
Here, we identify clinical laboratories who meet a minimum standard of data sharing:
To apply for status, or to update your status, laboratories can apply here.
Please note, changes to minimum requirements will go into effect January 1, 2020. Review revised requirements here.
|Laboratory||Meets requirements||Additional Achievements|
|Submitted evidence1||>75% from past 5 years2||Discrepancy resolution3||Consenting mechanism4|
|Athena Diagnostics Inc.||
|Centre for Mendelian Genomics, University Medical Centre Ljubljana||
|Center for Pediatric Genomic Medicine, Children's Mercy Hospital and Clinics|
|Color Genomics, Inc.||
|EGL Genetics (Emory)||
|Integrated Genetics/Laboratory Corporation of America|
|Partners Laboratory for Molecular Medicine||
|Phosphorus Diagnostics LLC||
|Quest Diagnostics Nichols Institute San Juan Capistrano||
|University of Chicago||
Some requirements and additional achievements based on self-reported data by laboratory
* Most recent submission pending ClinVar processing
1 Majority of submissions have evidence submitted (excludes allele-frequency classified variation)
2 >75% of classified sequence and/or copy number variants from past 5 years submitted
3 Actively working to resolve interlab interpretation differences
4 Laboratory actively supports use of a consenting mechanism to enable patients to directly consent to share detailed, individual-level clinical data (e.g., an internal patient registry made available for collaborative research, or report language highlighting external registries such as GenomeConnect)