The Hereditary Cancer Working Group aims to centralize and curate genetic knowledge in order to develop guidance for molecular diagnostic germline cancer testing.
- Identify laboratories that are generating data in the clinical domain to facilitate data submission to ClinVar
- Serve as the liaison between locus specific databases and similar research efforts to create partnerships with ClinVar “Expert Panel” status
- Implement the ClinGen Gene Curation Working Group’s “Clinical Validity classifications” and prioritize curation of genes on hereditary cancer panels
- Establish robust variant curation rules and processes for hereditary cancer genes