Mission Statement: The mission of the Cancer Somatic Workgroup is to facilitate the development of data curation interfaces and standards for interpretation of somatic changes and their clinical actionability in order to enhance the usability, dissemination and implementation of cancer somatic changes in the ClinGen resource to improve healthcare.
Vision Statement: The Cancer Somatic Workgroup aims to collaborate with expert groups to develop processes that support accurate determination of clinical relevance of somatic changes for use by physicians, clinical laboratories, researchers, and guideline-developing groups.
General WG Goals for 2018:
- Cancer variant curation
- Adoption of AMP guidelines by MVLD
- Develop and harden curation and workflow SOPs
Madhavan S1, Ritter D, Micheel C, Rao S, Roy A, Sonkin D, Mccoy M, Griffith M, Griffith OL, Mcgarvey P, Kulkarni S. (2018). ClinGen Cancer Somatic Working Group - standardizing and democratizing access to cancer molecular diagnostic data to drive translational research. Pacific Biosymposium of Biocomputing (23:247-258). PMID: 29218886
Ritter, D. I., Roychowdhury, S., Roy, A., Rao, S., Landrum, M. J., Sonkin, D., … on behalf of the ClinGen Somatic Cancer Working Group. (2016). Somatic cancer variant curation and harmonization through consensus minimum variant level data. Genome Medicine, 8, 117. http://doi.org/10.1186/s13073-016-0367-z
Integrating somatic variant data and biomarkers for germline variant classification in cancer predisposition genespublications - October 11, 2018
Somatic cancer variant curation and harmonization through consensus minimum variant level datapublications - November 1, 2016
Working Group Membership
Membership spans many fields, including genetics, medical, academia, and industry.